Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations

Abstract PRLΔE1, a retina-specific isoform of prolactin, is expressed in multiple and diverse forms of canine inherited retinal degeneration (IRD). We find that while PRLΔE1 expression in rods is not associated with the initial phase of disease characterized by acute photoreceptor cell death, it is...

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Bibliographic Details
Main Authors: Raghavi Sudharsan, Jennifer Kwok, Malgorzata Swider, Alexander Sumaroka, Gustavo D. Aguirre, Artur V. Cideciyan, William A. Beltran
Format: Article
Language:English
Published: Nature Publishing Group 2024-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07070-1
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