Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer

Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer

Objective: The cisplatin resistance significantly hinders the prospects for curing patients with advanced, recurrent, and metastatic cervical cancer (CC). Our study aims to clarify the mechanisms underlying cisplatin resistance in CC and provide a novel treatment strategy to overcome the cisplatin r...

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Bibliographic Details
Main Authors: Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Translational Oncology
Subjects:
Cervical cancer
Cisplatin sensitivity
Fatty acid synthase (FASN)
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001275
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