Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia
Background. Childhood AML patients are at increased risk for early fatal pulmonary complications. Pulmonary leukostasis and systemic inflammatory response syndrome (SIRS) following leukemia cell lysis are the likely etiologies. Observation. Soon after initiation of AML chemotherapy, an 18-month-old...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/640528 |
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| _version_ | 1832556780257804288 |
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| author | Michael Huang Erin Owen Scott Myers Ashok Raj |
| author_facet | Michael Huang Erin Owen Scott Myers Ashok Raj |
| author_sort | Michael Huang |
| collection | DOAJ |
| description | Background. Childhood AML patients are at increased risk for early fatal pulmonary complications. Pulmonary leukostasis and systemic inflammatory response syndrome (SIRS) following leukemia cell lysis are the likely etiologies. Observation. Soon after initiation of AML chemotherapy, an 18-month-old female who met SIRS criteria sustained cardiopulmonary failure requiring ECMO support. Upon recovery, the patient went on to complete therapy and remains in remission without permanent neurologic or cardiac sequelae. Conclusion. Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative. |
| format | Article |
| id | doaj-art-e3486c43a8794ba999021c86feb814ae |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-e3486c43a8794ba999021c86feb814ae2025-02-03T05:44:29ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/640528640528Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic LeukemiaMichael Huang0Erin Owen1Scott Myers2Ashok Raj3Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Louisville, Louisville, KY, USADivision of Pediatric Critical Care Medicine, University of Louisville, Louisville, KY, USADivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Louisville, Louisville, KY, USADivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Louisville, Louisville, KY, USABackground. Childhood AML patients are at increased risk for early fatal pulmonary complications. Pulmonary leukostasis and systemic inflammatory response syndrome (SIRS) following leukemia cell lysis are the likely etiologies. Observation. Soon after initiation of AML chemotherapy, an 18-month-old female who met SIRS criteria sustained cardiopulmonary failure requiring ECMO support. Upon recovery, the patient went on to complete therapy and remains in remission without permanent neurologic or cardiac sequelae. Conclusion. Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative.http://dx.doi.org/10.1155/2015/640528 |
| spellingShingle | Michael Huang Erin Owen Scott Myers Ashok Raj Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia Case Reports in Hematology |
| title | Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia |
| title_full | Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia |
| title_fullStr | Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia |
| title_full_unstemmed | Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia |
| title_short | Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia |
| title_sort | cardiopulmonary failure requiring ecmo bypass resulting from leukemia cell lysis in a patient with childhood acute myelomonocytic leukemia |
| url | http://dx.doi.org/10.1155/2015/640528 |
| work_keys_str_mv | AT michaelhuang cardiopulmonaryfailurerequiringecmobypassresultingfromleukemiacelllysisinapatientwithchildhoodacutemyelomonocyticleukemia AT erinowen cardiopulmonaryfailurerequiringecmobypassresultingfromleukemiacelllysisinapatientwithchildhoodacutemyelomonocyticleukemia AT scottmyers cardiopulmonaryfailurerequiringecmobypassresultingfromleukemiacelllysisinapatientwithchildhoodacutemyelomonocyticleukemia AT ashokraj cardiopulmonaryfailurerequiringecmobypassresultingfromleukemiacelllysisinapatientwithchildhoodacutemyelomonocyticleukemia |