Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism.

Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism.

Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug...

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Main Authors: Fruzsina Soltész, John Suckling, Phil Lawrence, Roger Tait, Cinly Ooi, Graham Bentley, Chris M Dodds, Sam R Miller, David R Wille, Misha Byrne, Simon M McHugh, Mark A Bellgrove, Rodney J Croft, Bai Lu, Edward T Bullmore, Pradeep J Nathan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095558&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095558&type=printable

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