Neurotensin(8-13) analogs targeting NTS1 and NTS2 receptors: A comparative in vitro and molecular modeling study

Neurotensin(8-13) analogs targeting NTS1 and NTS2 receptors: A comparative in vitro and molecular modeling study

The simultaneous activation of both neurotensin type 1 and 2 receptors (NTS1R and NTS2R) through the neuronal peptide neurotensin (NT), activating the dopamine (DA) release and DA signaling within the dopaminergic system in the brain, suggest that NTS1R/NTS2R dual-specific NT analogs may represent a...

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Bibliographic Details
Main Authors: Kiril Kirilov, Maria Ponticelli, Toni Kühl, Harald Hübner, Maya G. Georgieva, Matthias Vogel, Aneliya A. Balacheva, Bodo Haas, Tamara I. Pajpanova, Maima Matin, Luigi Milella, Peter Gmeiner, Diana Imhof, Nikolay T. Tzvetkov
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Biotechnology
Subjects:
In vitro studies
Neurotensin
Neurotensin receptors
Molecular Modeling
MD simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590262825000292
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