Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries
Background. Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods. We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in o...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/3413969 |
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| author | Hui-shan Wang Xian-xiu Ge Quan-peng Li Jun-jie Nie Lin Miao |
| author_facet | Hui-shan Wang Xian-xiu Ge Quan-peng Li Jun-jie Nie Lin Miao |
| author_sort | Hui-shan Wang |
| collection | DOAJ |
| description | Background. Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods. We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan–Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS). Results. Increased PT level was an effective predictor for OS (P = 0.021; hazard ratio (HR), 1.799) and RFS (P = 0.016; HR, 1.871) in CCA patients, independent of age, tumor differentiation, and TNM stage. In the low PT level group (PT < 12.3 s), patients showed a higher mean OS (23.03 m vs. 14.38 m, P = 0.0250) and RFS (17.78 m vs. 8.30 m, P = 0.0511) than those with high PT levels (PT ≥ 12.3 s). A highly significant association was observed between high PT level and shortened OS (P = 0.0373) and worse RFS (P = 0.0151). Conclusion. Preoperative increase in PT can serve as a simple but effective predictor of poor survival in CCA patients who undergo curative surgeries. |
| format | Article |
| id | doaj-art-e325668a2e424e18b4902bd9b896d83c |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-e325668a2e424e18b4902bd9b896d83c2025-02-03T06:08:29ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/34139693413969Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with SurgeriesHui-shan Wang0Xian-xiu Ge1Quan-peng Li2Jun-jie Nie3Lin Miao4Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 211166, Jiangsu Province, ChinaMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, ChinaMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, ChinaMedical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, ChinaNanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 211166, Jiangsu Province, ChinaBackground. Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods. We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan–Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS). Results. Increased PT level was an effective predictor for OS (P = 0.021; hazard ratio (HR), 1.799) and RFS (P = 0.016; HR, 1.871) in CCA patients, independent of age, tumor differentiation, and TNM stage. In the low PT level group (PT < 12.3 s), patients showed a higher mean OS (23.03 m vs. 14.38 m, P = 0.0250) and RFS (17.78 m vs. 8.30 m, P = 0.0511) than those with high PT levels (PT ≥ 12.3 s). A highly significant association was observed between high PT level and shortened OS (P = 0.0373) and worse RFS (P = 0.0151). Conclusion. Preoperative increase in PT can serve as a simple but effective predictor of poor survival in CCA patients who undergo curative surgeries.http://dx.doi.org/10.1155/2019/3413969 |
| spellingShingle | Hui-shan Wang Xian-xiu Ge Quan-peng Li Jun-jie Nie Lin Miao Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries Canadian Journal of Gastroenterology and Hepatology |
| title | Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries |
| title_full | Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries |
| title_fullStr | Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries |
| title_full_unstemmed | Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries |
| title_short | Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries |
| title_sort | clinical significance of prothrombin time in cholangiocarcinoma patients with surgeries |
| url | http://dx.doi.org/10.1155/2019/3413969 |
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