Phillyrin prevents sepsis-induced acute lung injury through inhibiting the NLRP3/caspase-1/GSDMD-dependent pyroptosis signaling pathway

Phillyrin prevents sepsis-induced acute lung injury through inhibiting the NLRP3/caspase-1/GSDMD-dependent pyroptosis signaling pathway

Acute lung injury (ALI) is a severe pulmonary disorder of sepsis with high clinical incidence and mortality. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)-cysteinyl aspartate specific prote...

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Bibliographic Details
Main Authors: Ji Chen, Hao Xiaoyan, Li Zhiyi, Liu Jiaxing, Yan Hanyu, Ma Ketao, Li Ling, Zhang Liang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-10-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
phillyrin
sepsis
acute lung injury
alveolar epithelial cells
pyroptosis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024161
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