Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study
Introduction This cohort study aimed to compare the effect of ultrasonic scaling on the expression of IL-1β in the gingival crevicular fluid (GCF) among ENDS users and non-smokers (NS) with gingivitis. Methods Self-reported current electronic nicotine delivery system (ENDS) users and NS with genera...
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| Format: | Article |
| Language: | English |
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European Publishing
2024-07-01
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| Series: | Tobacco Induced Diseases |
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| Online Access: | https://www.tobaccoinduceddiseases.org/Effect-of-scaling-on-levels-of-interleukin-1-beta-and-clinical-periodontal-parameters,189552,0,2.html |
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| author | Alaa B. Alkhalifah Nehad T. Alfuraih Bobby Joseph Jagan K. Baskaradoss |
| author_facet | Alaa B. Alkhalifah Nehad T. Alfuraih Bobby Joseph Jagan K. Baskaradoss |
| author_sort | Alaa B. Alkhalifah |
| collection | DOAJ |
| description | Introduction
This cohort study aimed to compare the effect of ultrasonic scaling
on the expression of IL-1β in the gingival crevicular fluid (GCF) among ENDS
users and non-smokers (NS) with gingivitis.
Methods
Self-reported current electronic nicotine delivery system (ENDS) users
and NS with generalized gingivitis were included in this study. All the patients
underwent scaling at the baseline visit (T0). Clinical measures, periodontal
parameters [probing depth (PD), plaque index (PI), and bleeding on probing
(BOP)], and GCF IL-1β were measured at T0, after 1 week (T1) and after 3 weeks
(T2). Wilcoxon signed rank test was used to assess the changes in the periodontal
measurements and IL-1β levels at different time points and Mann–Whitney U
Test was used to compare the two groups.
Results
A total of 38 individuals (18 NS and 20 ENDS users) participated in the
study. The PD was significantly higher in ENDS users than in NS at baseline.
However, the PI and BOP were similar in all groups at baseline. At T1, the PI was
significantly lower for NS than for ENDS users (p=0.045). At T2, there were no
significant differences in any of the parameters assessed between the two groups.
For ENDS users, BOP was significantly lower at T1 than at baseline. For NS, the
BOP at T1 and T2 and the PI at T1 were significantly lower than at baseline. There
was no difference in the GCF IL-1β levels in NS and ENDS users at baseline,
T1, and T2. At T2, there was a significant reduction in IL-1β (p<0.05) than at
baseline in both groups.
Conclusions
Both ENDS users and NS with gingivitis responded similarly to scaling.
GCF IL-1β levels were significantly higher at baseline (p<0.05) compared with
their levels at T1 and T2 for both the groups.
CLINICAL TRIAL REGISTRATION
The study was registered on the official website of ClinicalTrials.gov
IDENTIFIER
ID NCT05745324 |
| format | Article |
| id | doaj-art-e313687ace3d47ee8bf2d88601a094b8 |
| institution | Kabale University |
| issn | 1617-9625 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj-art-e313687ace3d47ee8bf2d88601a094b82025-01-24T15:27:00ZengEuropean PublishingTobacco Induced Diseases1617-96252024-07-0122July11010.18332/tid/189552189552Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective studyAlaa B. Alkhalifah0Nehad T. Alfuraih1Bobby Joseph2Jagan K. Baskaradoss3https://orcid.org/0000-0002-0032-0464College of Dentistry, Kuwait University, Kuwait City, State of KuwaitCollege of Dentistry, Kuwait University, Kuwait City, State of KuwaitOral Health Centre of Western Australia, The University of Western Australia Dental School, Nedlands, AustraliaDepartment of Developmental and Preventive Sciences, College of Dentistry, Kuwait University, Kuwait City, State of KuwaitIntroduction This cohort study aimed to compare the effect of ultrasonic scaling on the expression of IL-1β in the gingival crevicular fluid (GCF) among ENDS users and non-smokers (NS) with gingivitis. Methods Self-reported current electronic nicotine delivery system (ENDS) users and NS with generalized gingivitis were included in this study. All the patients underwent scaling at the baseline visit (T0). Clinical measures, periodontal parameters [probing depth (PD), plaque index (PI), and bleeding on probing (BOP)], and GCF IL-1β were measured at T0, after 1 week (T1) and after 3 weeks (T2). Wilcoxon signed rank test was used to assess the changes in the periodontal measurements and IL-1β levels at different time points and Mann–Whitney U Test was used to compare the two groups. Results A total of 38 individuals (18 NS and 20 ENDS users) participated in the study. The PD was significantly higher in ENDS users than in NS at baseline. However, the PI and BOP were similar in all groups at baseline. At T1, the PI was significantly lower for NS than for ENDS users (p=0.045). At T2, there were no significant differences in any of the parameters assessed between the two groups. For ENDS users, BOP was significantly lower at T1 than at baseline. For NS, the BOP at T1 and T2 and the PI at T1 were significantly lower than at baseline. There was no difference in the GCF IL-1β levels in NS and ENDS users at baseline, T1, and T2. At T2, there was a significant reduction in IL-1β (p<0.05) than at baseline in both groups. Conclusions Both ENDS users and NS with gingivitis responded similarly to scaling. GCF IL-1β levels were significantly higher at baseline (p<0.05) compared with their levels at T1 and T2 for both the groups. CLINICAL TRIAL REGISTRATION The study was registered on the official website of ClinicalTrials.gov IDENTIFIER ID NCT05745324https://www.tobaccoinduceddiseases.org/Effect-of-scaling-on-levels-of-interleukin-1-beta-and-clinical-periodontal-parameters,189552,0,2.htmlcigaretteelectronicgingivitisinterleukinsvaping |
| spellingShingle | Alaa B. Alkhalifah Nehad T. Alfuraih Bobby Joseph Jagan K. Baskaradoss Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study Tobacco Induced Diseases cigarette electronic gingivitis interleukins vaping |
| title | Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study |
| title_full | Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study |
| title_fullStr | Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study |
| title_full_unstemmed | Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study |
| title_short | Effect of scaling on levels of interleukin 1-beta and clinical periodontal parameters among e-cigarette users and non-smokers: A prospective study |
| title_sort | effect of scaling on levels of interleukin 1 beta and clinical periodontal parameters among e cigarette users and non smokers a prospective study |
| topic | cigarette electronic gingivitis interleukins vaping |
| url | https://www.tobaccoinduceddiseases.org/Effect-of-scaling-on-levels-of-interleukin-1-beta-and-clinical-periodontal-parameters,189552,0,2.html |
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