Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism
In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism, represented by molecular factors and cells of the immune...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/524743 |
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| author | Sergei N. Shchelkunov |
| author_facet | Sergei N. Shchelkunov |
| author_sort | Sergei N. Shchelkunov |
| collection | DOAJ |
| description | In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism, represented by molecular factors and cells of the immune system, we would not only comprehend better but also discover new patterns of organization and function of these most important reactions directed against infectious agents. Here, study of the orthopoxviruses pathogenic for humans, such as variola (smallpox), monkeypox, cowpox, and vaccinia viruses, may be most important. Analysis of the experimental data, presented in this paper, allows to infer that variola virus and other orthopoxviruses possess an unexampled set of genes whose protein products efficiently modulate the manifold defense mechanisms of the host organisms compared with the viruses from other families. |
| format | Article |
| id | doaj-art-e31054d75b5048db9b115cf3e89295e0 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-e31054d75b5048db9b115cf3e89295e02025-02-03T01:28:19ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/524743524743Orthopoxvirus Genes That Mediate Disease Virulence and Host TropismSergei N. Shchelkunov0Department of Genomic Research, State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region 630559, RussiaIn the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism, represented by molecular factors and cells of the immune system, we would not only comprehend better but also discover new patterns of organization and function of these most important reactions directed against infectious agents. Here, study of the orthopoxviruses pathogenic for humans, such as variola (smallpox), monkeypox, cowpox, and vaccinia viruses, may be most important. Analysis of the experimental data, presented in this paper, allows to infer that variola virus and other orthopoxviruses possess an unexampled set of genes whose protein products efficiently modulate the manifold defense mechanisms of the host organisms compared with the viruses from other families.http://dx.doi.org/10.1155/2012/524743 |
| spellingShingle | Sergei N. Shchelkunov Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism Advances in Virology |
| title | Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism |
| title_full | Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism |
| title_fullStr | Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism |
| title_full_unstemmed | Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism |
| title_short | Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism |
| title_sort | orthopoxvirus genes that mediate disease virulence and host tropism |
| url | http://dx.doi.org/10.1155/2012/524743 |
| work_keys_str_mv | AT sergeinshchelkunov orthopoxvirusgenesthatmediatediseasevirulenceandhosttropism |