Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA

Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA

Abstract Background Non-invasive urine tests for bladder cancer (BC) could reduce dependence on flexible cystoscopy for diagnosis and surveillance. Most recent developments in urine testing are based on targeted detection of genomic and/or epigenomic markers. We hypothesised that long-read whole-gen...

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Main Authors: Anshita Goel, Benjamin J. Tura, Joanne D. Stockton, Nicholas Tovey, Luke Ames, Andrew D. Beggs, Maurice P. Zeegers, Nicholas D. James, K. K. Cheng, Richard T. Bryan, Douglas G. Ward, Roland Arnold
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Clinical Epigenetics
Subjects:
Bladder cancer
Methylation
Long-read sequencing
Nanopore
Urine DNA
Online Access:https://doi.org/10.1186/s13148-025-01946-5
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https://doi.org/10.1186/s13148-025-01946-5

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