Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components
The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironm...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/7970385 |
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| author | Laween Meran Anna Baulies Vivian S. W. Li |
| author_facet | Laween Meran Anna Baulies Vivian S. W. Li |
| author_sort | Laween Meran |
| collection | DOAJ |
| description | The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironment including the adjacent Paneth cells, stromal cells, smooth muscle cells, and neural cells as well as the extracellular matrix together constitute the intestinal stem cell niche. A dynamic regulatory network exists among the epithelium, stromal cells, and the matrix via complex signal transduction to maintain tissue homeostasis. Dysregulation of these biological or mechanical signals could potentially lead to intestinal injury and disease. In this review, we discuss the role of different intestinal stem cell niche components and dissect the interaction between dynamic matrix factors and regulatory signalling during intestinal stem cell homeostasis. |
| format | Article |
| id | doaj-art-e301cc4ad6d742b7b1ca4c44b340fb17 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e301cc4ad6d742b7b1ca4c44b340fb172025-02-03T01:24:15ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/79703857970385Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular ComponentsLaween Meran0Anna Baulies1Vivian S. W. Li2The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKThe intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironment including the adjacent Paneth cells, stromal cells, smooth muscle cells, and neural cells as well as the extracellular matrix together constitute the intestinal stem cell niche. A dynamic regulatory network exists among the epithelium, stromal cells, and the matrix via complex signal transduction to maintain tissue homeostasis. Dysregulation of these biological or mechanical signals could potentially lead to intestinal injury and disease. In this review, we discuss the role of different intestinal stem cell niche components and dissect the interaction between dynamic matrix factors and regulatory signalling during intestinal stem cell homeostasis.http://dx.doi.org/10.1155/2017/7970385 |
| spellingShingle | Laween Meran Anna Baulies Vivian S. W. Li Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components Stem Cells International |
| title | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| title_full | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| title_fullStr | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| title_full_unstemmed | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| title_short | Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components |
| title_sort | intestinal stem cell niche the extracellular matrix and cellular components |
| url | http://dx.doi.org/10.1155/2017/7970385 |
| work_keys_str_mv | AT laweenmeran intestinalstemcellnichetheextracellularmatrixandcellularcomponents AT annabaulies intestinalstemcellnichetheextracellularmatrixandcellularcomponents AT vivianswli intestinalstemcellnichetheextracellularmatrixandcellularcomponents |