Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada
Few studies have evaluated the feasibility of delivering syphilis point-of-care (POC) testing in outreach (nonclinical) settings in resource rich countries. The objectives of the study were to evaluate the feasibility and diagnostic performance of performing both HIV and syphilis POC testing in outr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/819593 |
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| author | Joshua Bergman Jennifer Gratrix Sabrina Plitt Jayne Fenton Chris Archibald Tom Wong Ameeta E. Singh |
| author_facet | Joshua Bergman Jennifer Gratrix Sabrina Plitt Jayne Fenton Chris Archibald Tom Wong Ameeta E. Singh |
| author_sort | Joshua Bergman |
| collection | DOAJ |
| description | Few studies have evaluated the feasibility of delivering syphilis point-of-care (POC) testing in outreach (nonclinical) settings in resource rich countries. The objectives of the study were to evaluate the feasibility and diagnostic performance of performing both HIV and syphilis POC testing in outreach settings and to document new cases identified in the study population. 1,265 outreach testing visits were offered syphilis and HIV POC testing and 81.5% (n=1,031) consented to testing. In our population, the SD Bioline 3.0 Syphilis Test had a sensitivity of 85.3% [CI (68.9–95.0)], specificity of 100.0% [CI (99.6–100.0)], positive predictive value (PPV) of 100.0% [CI (88.1–100.0)], and negative predictive value (NPV) of 99.5% [CI (98.9–99.8)]. Test characteristics for the INSTI HIV-1/HIV-2 Antibody Test had a 100.0% sensitivity [CI (39.8–100.00], 99.8 specificity [CI (99.3–100)], 66.7% PPV [CI (22.3–95.7)], and 100.0% NPV [CI (99.6–100.0)]. Four new cases of syphilis and four new HIV cases were diagnosed. In summary, at risk population seeking STI testing found POC tests to be acceptable, the POC tests performed well in outreach settings, and new cases of syphilis and HIV were identified and linked to treatment and care. |
| format | Article |
| id | doaj-art-e2d7cfeb829145e69b14a3eb1bedb803 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | AIDS Research and Treatment |
| spelling | doaj-art-e2d7cfeb829145e69b14a3eb1bedb8032025-02-03T01:20:14ZengWileyAIDS Research and Treatment2090-12402090-12592013-01-01201310.1155/2013/819593819593Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, CanadaJoshua Bergman0Jennifer Gratrix1Sabrina Plitt2Jayne Fenton3Chris Archibald4Tom Wong5Ameeta E. Singh6Alberta Health Services, Edmonton STI Clinic, 3B20 1111 Jasper Avenue, Edmonton, Alberta, T5K 0L4, CanadaAlberta Health Services, Edmonton STI Clinic, 3B20 1111 Jasper Avenue, Edmonton, Alberta, T5K 0L4, CanadaPublic Health Agency of Canada, 130 Colonnade Road, A.L. 6501H, Ottawa, ON, K1A 0K9, CanadaProvincial Laboratory for Public Health, 8440-112 Street, Edmonton, AB, T6G 2J2, CanadaPublic Health Agency of Canada, 130 Colonnade Road, A.L. 6501H, Ottawa, ON, K1A 0K9, CanadaPublic Health Agency of Canada, 130 Colonnade Road, A.L. 6501H, Ottawa, ON, K1A 0K9, CanadaAlberta Health Services, Edmonton STI Clinic, 3B20 1111 Jasper Avenue, Edmonton, Alberta, T5K 0L4, CanadaFew studies have evaluated the feasibility of delivering syphilis point-of-care (POC) testing in outreach (nonclinical) settings in resource rich countries. The objectives of the study were to evaluate the feasibility and diagnostic performance of performing both HIV and syphilis POC testing in outreach settings and to document new cases identified in the study population. 1,265 outreach testing visits were offered syphilis and HIV POC testing and 81.5% (n=1,031) consented to testing. In our population, the SD Bioline 3.0 Syphilis Test had a sensitivity of 85.3% [CI (68.9–95.0)], specificity of 100.0% [CI (99.6–100.0)], positive predictive value (PPV) of 100.0% [CI (88.1–100.0)], and negative predictive value (NPV) of 99.5% [CI (98.9–99.8)]. Test characteristics for the INSTI HIV-1/HIV-2 Antibody Test had a 100.0% sensitivity [CI (39.8–100.00], 99.8 specificity [CI (99.3–100)], 66.7% PPV [CI (22.3–95.7)], and 100.0% NPV [CI (99.6–100.0)]. Four new cases of syphilis and four new HIV cases were diagnosed. In summary, at risk population seeking STI testing found POC tests to be acceptable, the POC tests performed well in outreach settings, and new cases of syphilis and HIV were identified and linked to treatment and care.http://dx.doi.org/10.1155/2013/819593 |
| spellingShingle | Joshua Bergman Jennifer Gratrix Sabrina Plitt Jayne Fenton Chris Archibald Tom Wong Ameeta E. Singh Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada AIDS Research and Treatment |
| title | Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada |
| title_full | Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada |
| title_fullStr | Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada |
| title_full_unstemmed | Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada |
| title_short | Feasibility and Field Performance of a Simultaneous Syphilis and HIV Point-of-Care Test Based Screening Strategy in at Risk Populations in Edmonton, Canada |
| title_sort | feasibility and field performance of a simultaneous syphilis and hiv point of care test based screening strategy in at risk populations in edmonton canada |
| url | http://dx.doi.org/10.1155/2013/819593 |
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