Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoE−/− mice through the miR-34a/FGF-21 axis

Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoE−/− mice through the miR-34a/FGF-21 axis

IntroductionIncreasing evidence indicates that cellular senescence is a significant risk factor for atherosclerosis (AS).MethodsIn the present study, we used an apolipoprotein E knockout (ApoE−/−) mouse model to address the effect of sodium nitrate on senescence accompanied by atherosclerosis. After...

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Bibliographic Details
Main Authors: Ning Tao, Zhichao He, Han Duan, Liang Wang, Jing Yi, Jingyuan Shao, Lin Lv, Junzhao Duan, Hu Cao, Xiwen Dong, Hua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
atherosclerosis
senescence
sodium nitrate
miR-34a
FGF21
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1562321/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1562321/full

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