The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas
Background. Gene expression profiles of 181 breast cancer samples were analyzed to identify prognostic features of nuclear receptors NR5A1 and NR5A2 based upon their associated transcriptional networks. Methods. A supervised network analysis approach was used to build the NR5A-mediated transcription...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2015/403576 |
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| author | Li-Yun Chang Li-Yu D. Liu Don A. Roth Wen-Hung Kuo Hsiao-Lin Hwa King-Jen Chang Fon-Jou Hsieh |
| author_facet | Li-Yun Chang Li-Yu D. Liu Don A. Roth Wen-Hung Kuo Hsiao-Lin Hwa King-Jen Chang Fon-Jou Hsieh |
| author_sort | Li-Yun Chang |
| collection | DOAJ |
| description | Background. Gene expression profiles of 181 breast cancer samples were analyzed to identify prognostic features of nuclear receptors NR5A1 and NR5A2 based upon their associated transcriptional networks. Methods. A supervised network analysis approach was used to build the NR5A-mediated transcriptional regulatory network. Other bioinformatic tools and statistical methods were utilized to confirm and extend results from the network analysis methodology. Results. NR5A2 expression is a negative factor in breast cancer prognosis in both ER(−) and ER(−)/ER(+) mixed cohorts. The clinical and cohort significance of NR5A2-mediated transcriptional activities indicates that it may have a significant role in attenuating grade development and cancer related signal transduction pathways. NR5A2 signature that conditions poor prognosis was identified based upon results from 15 distinct probes. Alternatively, the expression of NR5A1 predicts favorable prognosis when concurrent NR5A2 expression is low. A favorable signature of eight transcription factors mediated by NR5A1 was also identified. Conclusions. Correlation of poor prognosis and NR5A2 activity is identified by NR5A2-mediated 15-gene signature. NR5A2 may be a potential drug target for treating a subset of breast cancer tumors across breast cancer subtypes, especially ER(−) breast tumors. The favorable prognostic feature of NR5A1 is predicted by NR5A1-mediated 8-gene signature. |
| format | Article |
| id | doaj-art-e27ff4aa936d4d1199a3ac7e4552e9c7 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-e27ff4aa936d4d1199a3ac7e4552e9c72025-02-03T00:59:38ZengWileyInternational Journal of Genomics2314-436X2314-43782015-01-01201510.1155/2015/403576403576The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast CarcinomasLi-Yun Chang0Li-Yu D. Liu1Don A. Roth2Wen-Hung Kuo3Hsiao-Lin Hwa4King-Jen Chang5Fon-Jou Hsieh6Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 100, TaiwanBiometry Division, Department of Agronomy, National Taiwan University, Taipei 106, TaiwanDepartment of Molecular Biology, University of Wyoming, Laramie, WY 82071, USADepartment of Surgery, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Surgery, College of Medicine, National Taiwan University, Taipei 100, TaiwanDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 100, TaiwanBackground. Gene expression profiles of 181 breast cancer samples were analyzed to identify prognostic features of nuclear receptors NR5A1 and NR5A2 based upon their associated transcriptional networks. Methods. A supervised network analysis approach was used to build the NR5A-mediated transcriptional regulatory network. Other bioinformatic tools and statistical methods were utilized to confirm and extend results from the network analysis methodology. Results. NR5A2 expression is a negative factor in breast cancer prognosis in both ER(−) and ER(−)/ER(+) mixed cohorts. The clinical and cohort significance of NR5A2-mediated transcriptional activities indicates that it may have a significant role in attenuating grade development and cancer related signal transduction pathways. NR5A2 signature that conditions poor prognosis was identified based upon results from 15 distinct probes. Alternatively, the expression of NR5A1 predicts favorable prognosis when concurrent NR5A2 expression is low. A favorable signature of eight transcription factors mediated by NR5A1 was also identified. Conclusions. Correlation of poor prognosis and NR5A2 activity is identified by NR5A2-mediated 15-gene signature. NR5A2 may be a potential drug target for treating a subset of breast cancer tumors across breast cancer subtypes, especially ER(−) breast tumors. The favorable prognostic feature of NR5A1 is predicted by NR5A1-mediated 8-gene signature.http://dx.doi.org/10.1155/2015/403576 |
| spellingShingle | Li-Yun Chang Li-Yu D. Liu Don A. Roth Wen-Hung Kuo Hsiao-Lin Hwa King-Jen Chang Fon-Jou Hsieh The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas International Journal of Genomics |
| title | The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas |
| title_full | The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas |
| title_fullStr | The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas |
| title_full_unstemmed | The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas |
| title_short | The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas |
| title_sort | major prognostic features of nuclear receptor nr5a2 in infiltrating ductal breast carcinomas |
| url | http://dx.doi.org/10.1155/2015/403576 |
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