Iodine-Mediated Neutral and Selective N-Boc Deprotection
A simple, efficient, and alternative method has been developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under a solvent-free condition or in a solvent using iodine as a catalyst. The methodology involvin...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/916960 |
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| _version_ | 1832562084100964352 |
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| author | G. Pavan Kumar D. Rambabu M. V. Basaveswara Rao Manojit Pal |
| author_facet | G. Pavan Kumar D. Rambabu M. V. Basaveswara Rao Manojit Pal |
| author_sort | G. Pavan Kumar |
| collection | DOAJ |
| description | A simple, efficient, and alternative method has been developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under a solvent-free condition or in a solvent using iodine as a catalyst. The methodology involving the first use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to the previously reported methods. |
| format | Article |
| id | doaj-art-e27a8fa2e5cc432193830e854a00dc50 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e27a8fa2e5cc432193830e854a00dc502025-02-03T01:23:32ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/916960916960Iodine-Mediated Neutral and Selective N-Boc DeprotectionG. Pavan Kumar0D. Rambabu1M. V. Basaveswara Rao2Manojit Pal3Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510, IndiaDr. Reddy's Institute of Life Science, University of Hyderabad Campus, Hyderabad 500046, IndiaDepartment of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh 521001, IndiaDr. Reddy's Institute of Life Science, University of Hyderabad Campus, Hyderabad 500046, IndiaA simple, efficient, and alternative method has been developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under a solvent-free condition or in a solvent using iodine as a catalyst. The methodology involving the first use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to the previously reported methods.http://dx.doi.org/10.1155/2013/916960 |
| spellingShingle | G. Pavan Kumar D. Rambabu M. V. Basaveswara Rao Manojit Pal Iodine-Mediated Neutral and Selective N-Boc Deprotection Journal of Chemistry |
| title | Iodine-Mediated Neutral and Selective N-Boc Deprotection |
| title_full | Iodine-Mediated Neutral and Selective N-Boc Deprotection |
| title_fullStr | Iodine-Mediated Neutral and Selective N-Boc Deprotection |
| title_full_unstemmed | Iodine-Mediated Neutral and Selective N-Boc Deprotection |
| title_short | Iodine-Mediated Neutral and Selective N-Boc Deprotection |
| title_sort | iodine mediated neutral and selective n boc deprotection |
| url | http://dx.doi.org/10.1155/2013/916960 |
| work_keys_str_mv | AT gpavankumar iodinemediatedneutralandselectivenbocdeprotection AT drambabu iodinemediatedneutralandselectivenbocdeprotection AT mvbasaveswararao iodinemediatedneutralandselectivenbocdeprotection AT manojitpal iodinemediatedneutralandselectivenbocdeprotection |