Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agent

Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agent

Abstract Objective The present study aimed to synthesize flavone hybrids with 3-methoxy substitution and an N-heterocyclic ring at the 4ʹ position of the flavone B ring and test their effectiveness against cancer. Method Molecular docking of 3-methoxy flavone was studied on ER-α and EGFR. By cyclizi...

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Main Authors: Bharti S. Fegade, Somadatta Y. Chaudhari, Rupali V. Likhar, Ritesh P. Bhole, Pravin S. Uttekar, Sandeep S. Pathare, Swastika Maitra, Daniel Ejim Uti, Magdi E. A. Zaki, Esther Ugo Alum
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
3-Methoxy flavone
Flavonol
Breast cancer
MCF-7
MDA-MB-231
Online Access:https://doi.org/10.1007/s12672-025-02491-6
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https://doi.org/10.1007/s12672-025-02491-6

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