Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss

Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss

Abstract Volumetric muscle loss (VML) is a severe injury resulting in substantial skeletal muscle loss, leading to a complex pathology that culminates in suboptimal tissue repair and significant long-term functional deficits. This study employs a rodent model of VML to investigate the impact of biol...

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Bibliographic Details
Main Authors: Jessica M. Motherwell, Isabella J. Meerzaman, Sergey S. Kanovka, Michael S. Valerio, Claudia E. Hernandez, Zachary G. Davis, Andrew R. Clark, Stephen M. Goldman, Christopher L. Dearth
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sex characteristics
Wound healing
Skeletal muscle
Regeneration
Trauma
Online Access:https://doi.org/10.1038/s41598-025-05166-y
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https://doi.org/10.1038/s41598-025-05166-y

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