Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation
Introduction. Hodgkin lymphoma is a highly curable lymphoid malignancy; however treatment of a significant number of patients remains challenging. Case Report. The authors present an unusually rapidly progressing case of refractory advanced stage classical nodular sclerosis subtype Hodgkin lymphoma...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/7698624 |
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| author | Ádám Jóna Gábor Irsai Sándor Barna Gábor Méhes Árpád Illés László Váróczy |
| author_facet | Ádám Jóna Gábor Irsai Sándor Barna Gábor Méhes Árpád Illés László Váróczy |
| author_sort | Ádám Jóna |
| collection | DOAJ |
| description | Introduction. Hodgkin lymphoma is a highly curable lymphoid malignancy; however treatment of a significant number of patients remains challenging. Case Report. The authors present an unusually rapidly progressing case of refractory advanced stage classical nodular sclerosis subtype Hodgkin lymphoma with unfavorable prognosis. A 66-year-old male patient was refractory for first-line doxorubicin, bleomycin, vinblastin, dacarbazine (ABVD) treatment with persistent disease; therefore physicians changed treatment for dexamethasone, cytarabine, and cisplatin (DHAP) and later ifosfamide, gemcitabine, and vinorelbine (IGEV) regimen. Unfortunately the patient developed acute kidney and respiratory failure and died after 6 months of treatment. Current and retrospective histological examination of the patient’s lymph node biopsy, skin lesion, and autopsy revealed the same aberrantly expressing CD4 positive nodular sclerosis subtype Hodgkin lymphoma. Conclusion. Aberrant expression of T-cell antigens on the Hodgkin and Reed/Sternberg cells could be associated with inferior outcome. T-cell associated antigens should be investigated more often in patients not responding sufficiently to treatment and hence treatment should be intensified or targeted therapy (brentuximab vedotin) should be considered. |
| format | Article |
| id | doaj-art-e2609f9fc98440488e61fc965a07631f |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-e2609f9fc98440488e61fc965a07631f2025-02-03T01:22:20ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/76986247698624Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible ExplanationÁdám Jóna0Gábor Irsai1Sándor Barna2Gábor Méhes3Árpád Illés4László Váróczy5Department of Hematology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryDepartment of Pathology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryDepartment of Hematology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryDepartment of Pathology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryDepartment of Hematology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryDepartment of Hematology, Faculty of Medicine, University of Debrecen, Debrecen 4032, HungaryIntroduction. Hodgkin lymphoma is a highly curable lymphoid malignancy; however treatment of a significant number of patients remains challenging. Case Report. The authors present an unusually rapidly progressing case of refractory advanced stage classical nodular sclerosis subtype Hodgkin lymphoma with unfavorable prognosis. A 66-year-old male patient was refractory for first-line doxorubicin, bleomycin, vinblastin, dacarbazine (ABVD) treatment with persistent disease; therefore physicians changed treatment for dexamethasone, cytarabine, and cisplatin (DHAP) and later ifosfamide, gemcitabine, and vinorelbine (IGEV) regimen. Unfortunately the patient developed acute kidney and respiratory failure and died after 6 months of treatment. Current and retrospective histological examination of the patient’s lymph node biopsy, skin lesion, and autopsy revealed the same aberrantly expressing CD4 positive nodular sclerosis subtype Hodgkin lymphoma. Conclusion. Aberrant expression of T-cell antigens on the Hodgkin and Reed/Sternberg cells could be associated with inferior outcome. T-cell associated antigens should be investigated more often in patients not responding sufficiently to treatment and hence treatment should be intensified or targeted therapy (brentuximab vedotin) should be considered.http://dx.doi.org/10.1155/2016/7698624 |
| spellingShingle | Ádám Jóna Gábor Irsai Sándor Barna Gábor Méhes Árpád Illés László Váróczy Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation Case Reports in Medicine |
| title | Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation |
| title_full | Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation |
| title_fullStr | Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation |
| title_full_unstemmed | Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation |
| title_short | Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation |
| title_sort | rapidly progressing refractory hodgkin lymphoma a case report and a possible explanation |
| url | http://dx.doi.org/10.1155/2016/7698624 |
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