A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease

A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease

Amyloid-β (Aβ) is implicated in the pathophysiology of Alzheimer's disease (AD) and plays a significant role in neuronal degeneration. Aβ in solution is essential during the initial stages of developing lead compounds that influence Aβ fibrillation. The tendency of the Aβ peptide to misfold in...

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Bibliographic Details
Main Authors: Raja Chinnappan, Mateen A. Khan, Taj Mohammad, Sarah Mohammed Allwaibh, Shanmugam Easwaramoorthi, Ahmed Yaqinuddin, Sandhanasamy Devansan, Tanveer Ahmad Mir, Imtaiyaz Hassan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer's disease
mRA
fluorescent sensing probe
binding
thermodynamics
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1653063/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1653063/full

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