Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density

Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density

Early life stress (ELS) has lasting consequences on microglia and brain macrophage function. During ELS, microglia and brain macrophages alter their engagement with synapses leading to changes in neuronal excitability. Further, ELS can induce innate immune memory formation in microglia and brain mac...

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Bibliographic Details
Main Authors: Stephen C. Gironda, Samuel W. Centanni, Jeffrey L. Weiner
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Early life stress
Alcohol
Microglia
Light-Sheet Fluorescence Microscopy
CSF1R inhibition
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354624002114
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