miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path?
<b>Background:</b> Asymptomatic liver steatosis constitutes an emerging issue worldwide. Therefore, we decided to explore relationships between selected types of microRNAs (miRNAs), serological markers of liver fibrosis and hematological parameters in the course of non-alcoholic fatty li...
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2025-01-01
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| author | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Ilona Telejko Karolina Szczygieł Ewa Tywanek Halina Cichoż-Lach |
| author_facet | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Ilona Telejko Karolina Szczygieł Ewa Tywanek Halina Cichoż-Lach |
| author_sort | Agata Michalak |
| collection | DOAJ |
| description | <b>Background:</b> Asymptomatic liver steatosis constitutes an emerging issue worldwide. Therefore, we decided to explore relationships between selected types of microRNAs (miRNAs), serological markers of liver fibrosis and hematological parameters in the course of non-alcoholic fatty liver disease (NAFLD). <b>Methods:</b> Two hundred and seven persons were included in the survey: 97 with NAFLD and 110 healthy controls. Serological concentrations of miR-126-3p, miR-197-3p, and miR-1-3p were measured in all participants. Direct indices of liver fibrosis [procollagen I carboxyterminal propeptide (PICP), procollagen III aminoterminal propeptide (PIIINP), platelet-derived growth factor AB (PDGF-AB), transforming growth factor-α (TGF-α) and laminin] together with indirect markers (AAR, APRI, FIB-4 and GPR) were also evaluated. The assessment of hematological parameters concerned: mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), red blood cell distribution width (RDW), MPV to platelet (PLT) ratio (MPR), RDW to PLT ratio (RPR), neutrophil to lymphocyte (LYM) ratio (NLR), PLT to LYM ratio (PLR) and RDW to LYM ratio (RLR). Additionally, the NAFLD fibrosis score and BARD score were applied. <b>Results:</b> The concentration of miR-126-3p and miR-1-3p was higher, and miR-197-3p was lower in the NAFLD group (<i>p</i> < 0.0001). miR-197-3p correlated notably with hematological indices: negatively with PDW (<i>p</i> < 0.05) and positively with PLR (<i>p</i> < 0.05). <b>Conclusions:</b> Significant correlations between miRNA molecules and hematological markers in the course of NAFLD indicate inflammation as a potential background and create new possibilities for a diagnostic approach. |
| format | Article |
| id | doaj-art-e1fa0cb7c56b46dba9c732bba228bcf2 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-e1fa0cb7c56b46dba9c732bba228bcf22025-01-24T13:24:29ZengMDPI AGBiomedicines2227-90592025-01-0113123010.3390/biomedicines13010230miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path?Agata Michalak0Małgorzata Guz1Joanna Kozicka2Marek Cybulski3Witold Jeleniewicz4Ilona Telejko5Karolina Szczygieł6Ewa Tywanek7Halina Cichoż-Lach8Department of Gastroenterology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Gastroenterology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandClinical Dietetics Unit, Department of Bioanalytics, Medical University of Lublin, Chodźki 7, 20-093 Lublin, PolandDepartment of Internal Medicine and Internal Medicine in Nursing, Medical University of Lublin, Chodźki 7, 20-093 Lublin, PolandDepartment of Gastroenterology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland<b>Background:</b> Asymptomatic liver steatosis constitutes an emerging issue worldwide. Therefore, we decided to explore relationships between selected types of microRNAs (miRNAs), serological markers of liver fibrosis and hematological parameters in the course of non-alcoholic fatty liver disease (NAFLD). <b>Methods:</b> Two hundred and seven persons were included in the survey: 97 with NAFLD and 110 healthy controls. Serological concentrations of miR-126-3p, miR-197-3p, and miR-1-3p were measured in all participants. Direct indices of liver fibrosis [procollagen I carboxyterminal propeptide (PICP), procollagen III aminoterminal propeptide (PIIINP), platelet-derived growth factor AB (PDGF-AB), transforming growth factor-α (TGF-α) and laminin] together with indirect markers (AAR, APRI, FIB-4 and GPR) were also evaluated. The assessment of hematological parameters concerned: mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), red blood cell distribution width (RDW), MPV to platelet (PLT) ratio (MPR), RDW to PLT ratio (RPR), neutrophil to lymphocyte (LYM) ratio (NLR), PLT to LYM ratio (PLR) and RDW to LYM ratio (RLR). Additionally, the NAFLD fibrosis score and BARD score were applied. <b>Results:</b> The concentration of miR-126-3p and miR-1-3p was higher, and miR-197-3p was lower in the NAFLD group (<i>p</i> < 0.0001). miR-197-3p correlated notably with hematological indices: negatively with PDW (<i>p</i> < 0.05) and positively with PLR (<i>p</i> < 0.05). <b>Conclusions:</b> Significant correlations between miRNA molecules and hematological markers in the course of NAFLD indicate inflammation as a potential background and create new possibilities for a diagnostic approach.https://www.mdpi.com/2227-9059/13/1/230liver steatosisNAFLDliver disordersmiRNAsdiagnostic markershematological indices |
| spellingShingle | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Ilona Telejko Karolina Szczygieł Ewa Tywanek Halina Cichoż-Lach miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? Biomedicines liver steatosis NAFLD liver disorders miRNAs diagnostic markers hematological indices |
| title | miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? |
| title_full | miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? |
| title_fullStr | miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? |
| title_full_unstemmed | miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? |
| title_short | miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? |
| title_sort | mirnas and hematological markers in non alcoholic fatty liver disease a new diagnostic path |
| topic | liver steatosis NAFLD liver disorders miRNAs diagnostic markers hematological indices |
| url | https://www.mdpi.com/2227-9059/13/1/230 |
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