Lead bioaccumulation in human breast cancer tissue is associated with DNA instability and cell death resistance

Lead bioaccumulation in human breast cancer tissue is associated with DNA instability and cell death resistance

Abstract Lead (Pb) is increasingly recognized for its potential to alter cellular processes and contribute to cancer development. Although Pb is classified as a probable carcinogen by the IARC, the clinical evidence for its role in breast cancer is inconsistent and limited to epidemiological studies...

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Main Authors: Manuel Scimeca, Erica Giacobbi, Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Francesca Servadei, Daniel R. S. Middleton, Julia Bischof, Maria Paola Scioli, Giorgio Modesti, Eleonora Candi, Gerry Melino, Alessandro Mauriello
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02676-6
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https://doi.org/10.1038/s41420-025-02676-6

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