Uvarinol and Dichamanetin Derived from <i>Uvaria chamae</i> as Potential Dual-Site Inhibitors Against PBP2a in Methicillin Resistant <i>Staphylococcus aureus</i>: An In Silico Study

Uvarinol and Dichamanetin Derived from <i>Uvaria chamae</i> as Potential Dual-Site Inhibitors Against PBP2a in Methicillin Resistant <i>Staphylococcus aureus</i>: An In Silico Study

<b>Background/Objectives</b>: Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is one of the resistant pathogenic microorganisms that poses a global health threat due to its resistance to β-lactam antibiotics where the protein penicillin-binding protein 2a (PBP2a) pl...

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Main Authors: Emmanuel Ayodeji Agbebi, Shalom Oluwafunke Adeyemi, Adetola Ibukunoluwa Adewale, Omolara Seun Ajofoyinbo, Ezekiel Abiola Olugbogi, Oluwatoyin Mary Oyinloye, Iyadunni Adesola Anuoluwa, Timothy Oluwaseyi Agbebi, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)
penicillin-binding protein 2a (PBP2a)
<i>Uvaria chamae</i>
Uvarinol
Dichamanetin
Online Access:https://www.mdpi.com/1424-8247/18/4/529
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