Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension
Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabol...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/190923 |
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| author | Javed Y. Fowdar Marta V. Lason Attila L. Szvetko Rodney A. Lea Lyn R. Griffiths |
| author_facet | Javed Y. Fowdar Marta V. Lason Attila L. Szvetko Rodney A. Lea Lyn R. Griffiths |
| author_sort | Javed Y. Fowdar |
| collection | DOAJ |
| description | Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives. We genotyped two polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine synthase reductase gene (MTRR A66G), and one polymorphism in the methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their association with hypertension using chi-square analysis. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and EH. None of the four polymorphisms was significantly associated with EH and although we found a moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the association of the interaction model with EH was not statistically significant (P=0.2367). Our findings therefore suggest no individual or interactive association between four prominent Hcy pathway markers and EH. |
| format | Article |
| id | doaj-art-e18a8f222a5f43af9e22f880abdb3cb8 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-e18a8f222a5f43af9e22f880abdb3cb82025-02-03T05:45:55ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/190923190923Investigation of Homocysteine-Pathway-Related Variants in Essential HypertensionJaved Y. Fowdar0Marta V. Lason1Attila L. Szvetko2Rodney A. Lea3Lyn R. Griffiths4Genomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, AustraliaGenomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, AustraliaGenomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, AustraliaGenomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, AustraliaGenomics Research Centre, Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, QLD 4222, AustraliaHyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives. We genotyped two polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine synthase reductase gene (MTRR A66G), and one polymorphism in the methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their association with hypertension using chi-square analysis. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and EH. None of the four polymorphisms was significantly associated with EH and although we found a moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the association of the interaction model with EH was not statistically significant (P=0.2367). Our findings therefore suggest no individual or interactive association between four prominent Hcy pathway markers and EH.http://dx.doi.org/10.1155/2012/190923 |
| spellingShingle | Javed Y. Fowdar Marta V. Lason Attila L. Szvetko Rodney A. Lea Lyn R. Griffiths Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension International Journal of Hypertension |
| title | Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension |
| title_full | Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension |
| title_fullStr | Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension |
| title_full_unstemmed | Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension |
| title_short | Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension |
| title_sort | investigation of homocysteine pathway related variants in essential hypertension |
| url | http://dx.doi.org/10.1155/2012/190923 |
| work_keys_str_mv | AT javedyfowdar investigationofhomocysteinepathwayrelatedvariantsinessentialhypertension AT martavlason investigationofhomocysteinepathwayrelatedvariantsinessentialhypertension AT attilalszvetko investigationofhomocysteinepathwayrelatedvariantsinessentialhypertension AT rodneyalea investigationofhomocysteinepathwayrelatedvariantsinessentialhypertension AT lynrgriffiths investigationofhomocysteinepathwayrelatedvariantsinessentialhypertension |