Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

IntroductionThe potential for drug-induced gastrointestinal (GI) toxicity is significant, since the GI tract is one of the first barriers which come in to contact with oral drugs. In pharmaceutical research, the complex behavior of human intestinal cells is traditionally investigated using 2D cultur...

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Bibliographic Details
Main Authors: Stefanie Hoffmann, Philip Hewitt, Isabel Koscielski, Dorota Kurek, Wouter Strijker, Kinga Kosim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Drug Discovery
Subjects:
OrganoTEER
organ-on-chips
in vitro barrier model
drug toxicity
CaCo-2
preclinical safety
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2024.1459424/full
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https://www.frontiersin.org/articles/10.3389/fddsv.2024.1459424/full

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