Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk
Objective: Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optical coherence...
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000080 |
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| author | Esma Ecem Ersoy Ebubekir Durmuş |
| author_facet | Esma Ecem Ersoy Ebubekir Durmuş |
| author_sort | Esma Ecem Ersoy |
| collection | DOAJ |
| description | Objective: Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optical coherence tomography (EDI-OCT). Methods: A prospective cohort study included 51 acute CSCR patients and 51 healthy controls aged 18–65 years. Patients had symptoms for less than three months, with no prior treatment or ocular pathology. Participants with refractive errors of ±6D spherical or less and ±3D cylindrical or less were included, while with optic nerve/choroidal conditions, corticosteroid use, systemic diseases like sleep apnea, and media opacities were excluded. Comprehensive eye exams and EDI-OCT were performed to evaluate retinal, choroidal, and ONH parameters. Results: The mean subfoveal choroidal thickness (SFCT) (434.51±95.45 µm vs. 289.55±87.21 µm) and peripapillary choroidal thickness (PPCT) (282.12±79.14 µm vs. 180.79±53.99 µm) were significantly higher in the CSCR group compared to controls (p < 0.001 for both). Retinal nerve fiber layer (RNFL) (107.14±15.15 µm vs. 101.06±14.31 µm, p = 0.04) and lamina cribrosa thickness (LCT) (307.14±63.83 µm vs. 200.04±54.23 µm, p < 0.001) were significantly higher, while anterior laminar depth (ALD) and Bruch's membran opening-minimum rim width (BMO-MRW) were significantly lower in the acute CSCR. Conclusion: In acute CSCR, increased SFCT is accompanied by a corresponding rise in PPCT, leading to significant ONH structural changes and enhanced blood flow, potentially offering glaucoma protection. However, further research is needed to explore the long-term effects of chronic CSCR on choriocapillaris ischemia and optic nerve. |
| format | Article |
| id | doaj-art-e1872039efb14676823f5f4466a3ef60 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-e1872039efb14676823f5f4466a3ef602025-02-01T04:11:50ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104478Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma riskEsma Ecem Ersoy0Ebubekir Durmuş1Istanbul Medeniyet University, Faculty of Medicine, Department of Ophthalmology, Istanbul, TurkeyCorrespondence author at: Istanbul Medeniyet University, Göztepe Prof. Dr. Suleyman Yalçın City Hospital, Department of Ophthalmology, Kadiköy, Istanbul, Turkey.; Istanbul Medeniyet University, Faculty of Medicine, Department of Ophthalmology, Istanbul, TurkeyObjective: Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optical coherence tomography (EDI-OCT). Methods: A prospective cohort study included 51 acute CSCR patients and 51 healthy controls aged 18–65 years. Patients had symptoms for less than three months, with no prior treatment or ocular pathology. Participants with refractive errors of ±6D spherical or less and ±3D cylindrical or less were included, while with optic nerve/choroidal conditions, corticosteroid use, systemic diseases like sleep apnea, and media opacities were excluded. Comprehensive eye exams and EDI-OCT were performed to evaluate retinal, choroidal, and ONH parameters. Results: The mean subfoveal choroidal thickness (SFCT) (434.51±95.45 µm vs. 289.55±87.21 µm) and peripapillary choroidal thickness (PPCT) (282.12±79.14 µm vs. 180.79±53.99 µm) were significantly higher in the CSCR group compared to controls (p < 0.001 for both). Retinal nerve fiber layer (RNFL) (107.14±15.15 µm vs. 101.06±14.31 µm, p = 0.04) and lamina cribrosa thickness (LCT) (307.14±63.83 µm vs. 200.04±54.23 µm, p < 0.001) were significantly higher, while anterior laminar depth (ALD) and Bruch's membran opening-minimum rim width (BMO-MRW) were significantly lower in the acute CSCR. Conclusion: In acute CSCR, increased SFCT is accompanied by a corresponding rise in PPCT, leading to significant ONH structural changes and enhanced blood flow, potentially offering glaucoma protection. However, further research is needed to explore the long-term effects of chronic CSCR on choriocapillaris ischemia and optic nerve.http://www.sciencedirect.com/science/article/pii/S1572100025000080Central serous chorioretinopathyPeripapillary choroidal thicknessRetinal nerve fiber layerOptic nerve head structural parametersGlaucomaOCT |
| spellingShingle | Esma Ecem Ersoy Ebubekir Durmuş Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk Photodiagnosis and Photodynamic Therapy Central serous chorioretinopathy Peripapillary choroidal thickness Retinal nerve fiber layer Optic nerve head structural parameters Glaucoma OCT |
| title | Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk |
| title_full | Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk |
| title_fullStr | Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk |
| title_full_unstemmed | Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk |
| title_short | Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk |
| title_sort | optic nerve head changes in acute central serous chorioretinopathy implications for glaucoma risk |
| topic | Central serous chorioretinopathy Peripapillary choroidal thickness Retinal nerve fiber layer Optic nerve head structural parameters Glaucoma OCT |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000080 |
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