MLN0905 effectively kills gemcitabine-resistant pancreatic cancer cells by targeting PLK1
Abstract Background Polo-like kinase 1 (PLK1) functionally mediates tumorigenesis of pancreatic cancer (PC) and associates with its drug resistance to gemcitabine, but related inhibitor therapies were poorly explored. MLN0905 is a novel small molecule inhibitor targeting PLK1. Here we investigate th...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02825-8 |
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