PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation
PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells.
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| Format: | Article |
| Language: | English |
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Sciendo
2016-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0031 |
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| author | Mabeta Peace |
| author_facet | Mabeta Peace |
| author_sort | Mabeta Peace |
| collection | DOAJ |
| description | PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells. |
| format | Article |
| id | doaj-art-e17d04c4d5224207a0cf4135975e6d77 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e17d04c4d5224207a0cf4135975e6d772025-02-02T11:59:26ZengSciendoActa Pharmaceutica1846-95582016-09-0166339941010.1515/acph-2016-0031acph-2016-0031PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylationMabeta Peace0Angiogenesis Laboratory Department of Anatomy and Physiology University of Pretoria, Private Bag X04 Tshwane, 0110, South AfricaPF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells.https://doi.org/10.1515/acph-2016-0031pf573,228focal adhesion kinaseendotheliomaapoptosisangiogenesis |
| spellingShingle | Mabeta Peace PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation Acta Pharmaceutica pf573,228 focal adhesion kinase endothelioma apoptosis angiogenesis |
| title | PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation |
| title_full | PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation |
| title_fullStr | PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation |
| title_full_unstemmed | PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation |
| title_short | PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation |
| title_sort | pf573 228 inhibits vascular tumor cell growth migration as well as angiogenesis induces apoptosis and abrogates pras40 and s6rp phosphorylation |
| topic | pf573,228 focal adhesion kinase endothelioma apoptosis angiogenesis |
| url | https://doi.org/10.1515/acph-2016-0031 |
| work_keys_str_mv | AT mabetapeace pf573228inhibitsvasculartumorcellgrowthmigrationaswellasangiogenesisinducesapoptosisandabrogatespras40ands6rpphosphorylation |