Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula
Abstract Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate. Herein, a new class of quaternized molecu...
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Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202407537 |
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| author | Runxian Wang Pengwei Ma Siqi He Xiao Wang Jinquan Zhang Junwen Ye Mingli Su Xingxing Shi Ruoxu Dou |
| author_facet | Runxian Wang Pengwei Ma Siqi He Xiao Wang Jinquan Zhang Junwen Ye Mingli Su Xingxing Shi Ruoxu Dou |
| author_sort | Runxian Wang |
| collection | DOAJ |
| description | Abstract Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate. Herein, a new class of quaternized molecular brush‐grafted injectable microgel (denoted as GAA@CNT‐g‐PVBTMA) is developed through thermal polymerization and mechanical fragmentation to promote the healing process of anal fistula. Benefiting from the fragmented morphology with a porous structure, the microgel can effectively fill the fistula and facilitate the drainage of exudate. Owing to the electrostatic interactions between the positively charged quaternized carbon nanotube molecular brush (CNT‐g‐PVBTMA) and the negatively charged inflammatory cytokines, GAA@CNT‐g‐PVBTMA microgel exhibits excellent anti‐inflammatory properties with scavenging rates of 92.6% for tumor necrosis factor‐α (TNF‐α) and 92.5% for interleukin‐1β (IL‐1β). Rat inflammatory anal fistula model demonstrates that the microgel can effectively reduce inflammation and epithelialization of the fistula, thereby promoting the healing of the anal fistula. By integrating effective filling, adequate drainage, and excellent anti‐inflammatory properties, GAA@CNT‐g‐PVBTMA microgel provides a promising new direction for the treatment of anal fistula. |
| format | Article |
| id | doaj-art-e1792a36a1b24f938cf2783d14e79b18 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-e1792a36a1b24f938cf2783d14e79b182025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202407537Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal FistulaRunxian Wang0Pengwei Ma1Siqi He2Xiao Wang3Jinquan Zhang4Junwen Ye5Mingli Su6Xingxing Shi7Ruoxu Dou8The Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai 519000 P. R. ChinaSchool of Chemistry Sun Yat‐sen University Guangzhou 510006 P. R. ChinaThe Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai 519000 P. R. ChinaThe Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai 519000 P. R. ChinaThe Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai 519000 P. R. ChinaDepartment of General Surgery (Colorectal Surgery) Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat‐sen University Guangzhou 510655 P. R. ChinaDepartment of General Surgery (Endoscopic Surgery) Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat‐sen University Guangzhou 510655 P. R. ChinaThe Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 P. R. ChinaThe Fifth Affiliated Hospital Sun Yat‐sen University Zhuhai 519000 P. R. ChinaAbstract Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate. Herein, a new class of quaternized molecular brush‐grafted injectable microgel (denoted as GAA@CNT‐g‐PVBTMA) is developed through thermal polymerization and mechanical fragmentation to promote the healing process of anal fistula. Benefiting from the fragmented morphology with a porous structure, the microgel can effectively fill the fistula and facilitate the drainage of exudate. Owing to the electrostatic interactions between the positively charged quaternized carbon nanotube molecular brush (CNT‐g‐PVBTMA) and the negatively charged inflammatory cytokines, GAA@CNT‐g‐PVBTMA microgel exhibits excellent anti‐inflammatory properties with scavenging rates of 92.6% for tumor necrosis factor‐α (TNF‐α) and 92.5% for interleukin‐1β (IL‐1β). Rat inflammatory anal fistula model demonstrates that the microgel can effectively reduce inflammation and epithelialization of the fistula, thereby promoting the healing of the anal fistula. By integrating effective filling, adequate drainage, and excellent anti‐inflammatory properties, GAA@CNT‐g‐PVBTMA microgel provides a promising new direction for the treatment of anal fistula.https://doi.org/10.1002/advs.202407537anal fistulaanti‐inflammatorycarbon nanotubeinjectable microgelquaternized molecular brush |
| spellingShingle | Runxian Wang Pengwei Ma Siqi He Xiao Wang Jinquan Zhang Junwen Ye Mingli Su Xingxing Shi Ruoxu Dou Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula Advanced Science anal fistula anti‐inflammatory carbon nanotube injectable microgel quaternized molecular brush |
| title | Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula |
| title_full | Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula |
| title_fullStr | Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula |
| title_full_unstemmed | Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula |
| title_short | Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula |
| title_sort | quaternized molecular brush grafted injectable microgel with anti inflammatory and drainage properties for efficient therapy of anal fistula |
| topic | anal fistula anti‐inflammatory carbon nanotube injectable microgel quaternized molecular brush |
| url | https://doi.org/10.1002/advs.202407537 |
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