Therapeutic effect of miR-30b-5p-loaded lentivirus on experimental autoimmune uveitis via inhibiting Notch signaling activation

Therapeutic effect of miR-30b-5p-loaded lentivirus on experimental autoimmune uveitis via inhibiting Notch signaling activation

Abstract Background Uveitis is a common recurrent autoimmune disease that seriously endangers the visual health of patients. MicroRNAs (miRNAs) are closely related to a series of autoimmune diseases. Methods The present study aimed to investigate the effect of miR-30b-5p on experimental autoimmune u...

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Main Authors: Xuewei Yin, Huixia Wei, Lijie Guo, Bin Liu, Yuan Peng, Mengxian Zhou, Yan Qiu, Ruyi Qu, Yane Gao, Qiuxin Wu, Wenjun Jiang, Hongsheng Bi, Dadong Guo
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Experimental autoimmune uveitis
Notch signaling pathway
miR-30b-5p
Th cell
Notch1
Dll4
Online Access:https://doi.org/10.1186/s12967-025-06438-x
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https://doi.org/10.1186/s12967-025-06438-x

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