Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies

Abstract Combination antiretroviral therapy controls human immunodeficiency virus-1 (HIV) but cannot eradicate latent proviruses in immune cells, which reactivate upon treatment interruption. Anti-latency therapies like “shock-and-kill” are being developed but are yet to succeed due to the complexit...

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Bibliographic Details
Main Authors: Gianmarco Rasi, Elena Emili, Jessica M. Conway, Nicola Cotugno, Paolo Palma
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00538-6
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