Hydroxysafflor Yellow A modulation of metabolite networks and inhibition of JAK2/STAT1 pathway in sepsis

Hydroxysafflor Yellow A modulation of metabolite networks and inhibition of JAK2/STAT1 pathway in sepsis

Abstract Sepsis, a severe infectious disease causing multiple organ dysfunction, requires further exploration of its pathomechanisms and therapeutic options. Hydroxysafflor Yellow A (HYSA), extracted from Carthamus tinctorius L, has shown anti-inflammatory and antioxidant properties effective in tre...

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Bibliographic Details
Main Authors: Bingbing Pan, Fengting Chen, Siyan Shen, Yu Jiang, Ying Yang, Jia Wang, Yanjuan Liu, Lai Wei, Jitong Liu, Gaoyin Kong, Xuan He, Bing Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hydroxysafflor Yellow A
Sepsis
Multi-organ damage
Metabolomics
Network pharmacology
JAK2/STAT1
Online Access:https://doi.org/10.1038/s41598-025-11545-2
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