PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor for HCC. Peroxisome prolife...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/574180 |
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| _version_ | 1832560907805261824 |
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| author | Osamu Kimura Yasuteru Kondo Tooru Shimosegawa |
| author_facet | Osamu Kimura Yasuteru Kondo Tooru Shimosegawa |
| author_sort | Osamu Kimura |
| collection | DOAJ |
| description | Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor for HCC. Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. PPARs could contribute to the mechanisms of cell cycling, anti-inflammatory responses, and apoptosis. Therefore, to clarify the pathogenesis of HCC, we should examine PPAR signaling. In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling. |
| format | Article |
| id | doaj-art-e15445ee33f54a5e9c36e0099bec50f0 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-e15445ee33f54a5e9c36e0099bec50f02025-02-03T01:26:33ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/574180574180PPAR Could Contribute to the Pathogenesis of Hepatocellular CarcinomaOsamu Kimura0Yasuteru Kondo1Tooru Shimosegawa2Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba-ku, Sendai City, Miyagi 980-8574, JapanDivision of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba-ku, Sendai City, Miyagi 980-8574, JapanDivision of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba-ku, Sendai City, Miyagi 980-8574, JapanViral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor for HCC. Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. PPARs could contribute to the mechanisms of cell cycling, anti-inflammatory responses, and apoptosis. Therefore, to clarify the pathogenesis of HCC, we should examine PPAR signaling. In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling.http://dx.doi.org/10.1155/2012/574180 |
| spellingShingle | Osamu Kimura Yasuteru Kondo Tooru Shimosegawa PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma PPAR Research |
| title | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
| title_full | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
| title_fullStr | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
| title_full_unstemmed | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
| title_short | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma |
| title_sort | ppar could contribute to the pathogenesis of hepatocellular carcinoma |
| url | http://dx.doi.org/10.1155/2012/574180 |
| work_keys_str_mv | AT osamukimura pparcouldcontributetothepathogenesisofhepatocellularcarcinoma AT yasuterukondo pparcouldcontributetothepathogenesisofhepatocellularcarcinoma AT toorushimosegawa pparcouldcontributetothepathogenesisofhepatocellularcarcinoma |