Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

Abstract Objective Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency and severity of cisplatin-induced AKI. This study evaluated bardoxolone methyl (BARD) as a nephroprot...

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Bibliographic Details
Main Authors: Lauren E. Thompson, Stacey M. Tuey, Paola Garcia Gonzalez, Carly S. Chesterman, Courtney D. McGinnis, M. Scott Lucia, Lauren M. Aleksunes, Charles L. Edelstein, Melanie S. Joy
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:AAPS Open
Subjects:
Cisplatin
Nephrotoxicity
Bardoxolone Methyl
Acute Kidney Injury
Nrf2
Online Access:https://doi.org/10.1186/s41120-025-00107-5
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https://doi.org/10.1186/s41120-025-00107-5

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