SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin

Abstract Purpose Growing evidence suggests that the tyrosine phosphatase SHP2 is pivotal for tumor progression. Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, characterized by its high recurrence rate, aggressive metastasis, and resistance to chemotherapy. Understa...

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Bibliographic Details
Main Authors: Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Journal of Cancer Research and Clinical Oncology
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Online Access:https://doi.org/10.1007/s00432-025-06097-x
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