Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy
Introduction. Small cell neuroendocrine carcinomas of the urinary tract is an extremely rare entity and very few cases have been reported in the literature. Small cell neuroendocrine carcinoma of the urinary tract (SCC-UT) is the association between bladder and urinary upper tract-small cell carcino...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2013/598325 |
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| author | Mustapha Ahsaini Omar Riyach Mohammed Fadl Tazi Mohammed Jamal El Fassi My Hassan Farih Hind Elfatmi Afaf Amarti |
| author_facet | Mustapha Ahsaini Omar Riyach Mohammed Fadl Tazi Mohammed Jamal El Fassi My Hassan Farih Hind Elfatmi Afaf Amarti |
| author_sort | Mustapha Ahsaini |
| collection | DOAJ |
| description | Introduction. Small cell neuroendocrine carcinomas of the urinary tract is an extremely rare entity and very few cases have been reported in the literature. Small cell neuroendocrine carcinoma of the urinary tract (SCC-UT) is the association between bladder and urinary upper tract-small cell carcinoma (UUT-SCC). It characterized by an aggressive clinical course. The prognosis is poor due to local or distant metastases, and usually the muscle of the bladder is invaded. Case Presentation. We report a rare case of a 54-year-old Arab male native of moroccan; he is a smoker and was referred to our institution for intermittent hematuria. Following a diagnosis of small cell neuroendocrine carcinomas of the ureter and the bladder, thoracoabdominal-pelvic CT was done, and the staging of the tumor was done in the bladder (T2N0M0) and (T1N0M0) in the ureter. Neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin was realized, and nephroureterectomy associated to a cystoprostatectomy was carried out. After 24 months of followup, no local or distant metastasis was detected. Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors. |
| format | Article |
| id | doaj-art-e11d59ba9e5942619b3c991dda5b6be7 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-e11d59ba9e5942619b3c991dda5b6be72025-02-03T01:03:25ZengWileyCase Reports in Urology2090-696X2090-69782013-01-01201310.1155/2013/598325598325Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant ChemotherapyMustapha Ahsaini0Omar Riyach1Mohammed Fadl Tazi2Mohammed Jamal El Fassi3My Hassan Farih4Hind Elfatmi5Afaf Amarti6Department of Urology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Urology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Urology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Urology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Urology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Pathology, University Hospital Center Hassan II, 30000 Fez, MoroccoDepartment of Pathology, University Hospital Center Hassan II, 30000 Fez, MoroccoIntroduction. Small cell neuroendocrine carcinomas of the urinary tract is an extremely rare entity and very few cases have been reported in the literature. Small cell neuroendocrine carcinoma of the urinary tract (SCC-UT) is the association between bladder and urinary upper tract-small cell carcinoma (UUT-SCC). It characterized by an aggressive clinical course. The prognosis is poor due to local or distant metastases, and usually the muscle of the bladder is invaded. Case Presentation. We report a rare case of a 54-year-old Arab male native of moroccan; he is a smoker and was referred to our institution for intermittent hematuria. Following a diagnosis of small cell neuroendocrine carcinomas of the ureter and the bladder, thoracoabdominal-pelvic CT was done, and the staging of the tumor was done in the bladder (T2N0M0) and (T1N0M0) in the ureter. Neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin was realized, and nephroureterectomy associated to a cystoprostatectomy was carried out. After 24 months of followup, no local or distant metastasis was detected. Conclusion. The purpose of this review is to present a rare case of pure small cell neuroendocrine carcinoma of the urinary tract and review the literature about the place of neoadjuvant chemotherapy in this rare tumors.http://dx.doi.org/10.1155/2013/598325 |
| spellingShingle | Mustapha Ahsaini Omar Riyach Mohammed Fadl Tazi Mohammed Jamal El Fassi My Hassan Farih Hind Elfatmi Afaf Amarti Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy Case Reports in Urology |
| title | Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy |
| title_full | Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy |
| title_fullStr | Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy |
| title_full_unstemmed | Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy |
| title_short | Small Cell Neuroendocrine Carcinoma of the Urinary Tract Successfully Managed with Neoadjuvant Chemotherapy |
| title_sort | small cell neuroendocrine carcinoma of the urinary tract successfully managed with neoadjuvant chemotherapy |
| url | http://dx.doi.org/10.1155/2013/598325 |
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