Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

ABSTRACT Hepatocellular carcinoma (HCC) is a deadly disease characterized by a high mortality rate and resistance to conventional therapies, highlighting the need for novel therapeutic interventions. Given the multifaceted nature of HCC pathogenesis, a multitargeted and polypharmacological approach...

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Bibliographic Details
Main Authors: Shakeel Ahmad Khan, Huihai Yang, Fan Ying, Chin Ngok Chu, Terence Kin Wah Lee
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
benzoxazinone derivatives
hepatocellular carcinoma
multi‐targeted therapy
polypharmacology
tumor suppression
Online Access:https://doi.org/10.1002/mco2.70291
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https://doi.org/10.1002/mco2.70291

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