Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country
Introduction. Acute diarrheal disease (ADD) is a common cause of morbidity and mortality in children under 5 years of age. Understanding of the etiology of ADD is lacking in most low and middle income countries because reference laboratories detect limited number of pathogens. The objective of this...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/6357597 |
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| author | Ana E. Farfán-García Chengxian Zhang Aamer Imdad Monica Y. Arias-Guerrero Nayibe T. Sánchez-Alvarez Rikhil Shah Junaid Iqbal Maria E. Tamborski Oscar G. Gómez-Duarte |
| author_facet | Ana E. Farfán-García Chengxian Zhang Aamer Imdad Monica Y. Arias-Guerrero Nayibe T. Sánchez-Alvarez Rikhil Shah Junaid Iqbal Maria E. Tamborski Oscar G. Gómez-Duarte |
| author_sort | Ana E. Farfán-García |
| collection | DOAJ |
| description | Introduction. Acute diarrheal disease (ADD) is a common cause of morbidity and mortality in children under 5 years of age. Understanding of the etiology of ADD is lacking in most low and middle income countries because reference laboratories detect limited number of pathogens. The objective of this study was to determine the feasibility to conduct a comprehensive case-control study to survey diarrheal pathogens among children with and without moderate-to-severe ADD. Materials and Methods. Microbiology and molecular-based techniques were used to detect viral, bacterial, and parasitic enteropathogens. The study was conducted in Bucaramanga, Colombia, after Institutional Review Board approval was obtained. Results. Ninety children less than 5 years of age were recruited after a written informed consent was obtained from parents or guardians. Forty-five subjects served as cases with ADD and 45 as controls. Thirty-six subjects out of 90 (40.0%) were positive for at least one enteropathogen, that is, 20 (44.4%) cases and 16 (35.5%) controls. Conclusions. The three most common enteric pathogens were enteroaggregative E. coli (10.0%), Norovirus (6.7%), and Salmonella spp. (5.6%). The E. coli pathogens were 18.8% of all infections making them the most frequent pathogens. Half of ADD cases were negative for any pathogens. |
| format | Article |
| id | doaj-art-e106f52c3e2045dfb2564ee11f740dff |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-e106f52c3e2045dfb2564ee11f740dff2025-02-03T06:07:08ZengWileyInternational Journal of Pediatrics1687-97401687-97592017-01-01201710.1155/2017/63575976357597Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income CountryAna E. Farfán-García0Chengxian Zhang1Aamer Imdad2Monica Y. Arias-Guerrero3Nayibe T. Sánchez-Alvarez4Rikhil Shah5Junaid Iqbal6Maria E. Tamborski7Oscar G. Gómez-Duarte8Grupo de Investigación en Manejo Clínico (CliniUDES), Programa de Bacteriología y Laboratorio Clínico, Facultad de Ciencias de la Salud, Universidad de Santander (UDES), Bucaramanga, ColombiaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USADivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USAGrupo de Investigación en Manejo Clínico (CliniUDES), Programa de Bacteriología y Laboratorio Clínico, Facultad de Ciencias de la Salud, Universidad de Santander (UDES), Bucaramanga, ColombiaGrupo de Investigación en Manejo Clínico (CliniUDES), Programa de Bacteriología y Laboratorio Clínico, Facultad de Ciencias de la Salud, Universidad de Santander (UDES), Bucaramanga, ColombiaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USADivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USADivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USADivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USAIntroduction. Acute diarrheal disease (ADD) is a common cause of morbidity and mortality in children under 5 years of age. Understanding of the etiology of ADD is lacking in most low and middle income countries because reference laboratories detect limited number of pathogens. The objective of this study was to determine the feasibility to conduct a comprehensive case-control study to survey diarrheal pathogens among children with and without moderate-to-severe ADD. Materials and Methods. Microbiology and molecular-based techniques were used to detect viral, bacterial, and parasitic enteropathogens. The study was conducted in Bucaramanga, Colombia, after Institutional Review Board approval was obtained. Results. Ninety children less than 5 years of age were recruited after a written informed consent was obtained from parents or guardians. Forty-five subjects served as cases with ADD and 45 as controls. Thirty-six subjects out of 90 (40.0%) were positive for at least one enteropathogen, that is, 20 (44.4%) cases and 16 (35.5%) controls. Conclusions. The three most common enteric pathogens were enteroaggregative E. coli (10.0%), Norovirus (6.7%), and Salmonella spp. (5.6%). The E. coli pathogens were 18.8% of all infections making them the most frequent pathogens. Half of ADD cases were negative for any pathogens.http://dx.doi.org/10.1155/2017/6357597 |
| spellingShingle | Ana E. Farfán-García Chengxian Zhang Aamer Imdad Monica Y. Arias-Guerrero Nayibe T. Sánchez-Alvarez Rikhil Shah Junaid Iqbal Maria E. Tamborski Oscar G. Gómez-Duarte Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country International Journal of Pediatrics |
| title | Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country |
| title_full | Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country |
| title_fullStr | Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country |
| title_full_unstemmed | Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country |
| title_short | Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country |
| title_sort | case control pilot study on acute diarrheal disease in a geographically defined pediatric population in a middle income country |
| url | http://dx.doi.org/10.1155/2017/6357597 |
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