Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish

Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish

Reactive oxygen species (ROS) within the retina play a key role in maintaining function and cell survival. However, excessive ROS can lead to oxidative stress, inducing dysregulation of metabolic and inflammatory pathways. The <i>chm<sup>ru848</sup></i> zebrafish models choro...

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Main Authors: Cécile Méjécase, Neelima Nair, Hajrah Sarkar, Pablo Soro-Barrio, Maria Toms, Sophia Halliday, Katy Linkens, Natalia Jaroszynska, Constance Maurer, Nicholas Owen, Mariya Moosajee
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
CHM
choroideremia
zebrafish
oxidative stress
glucose metabolism
inherited retinal diseases
Online Access:https://www.mdpi.com/2076-3921/13/12/1587
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