One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid
An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2005/237237 |
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| _version_ | 1832545477010128896 |
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| author | Jin Tong-Shou Zhao Ying Liu Li-Bin Li Tong-Shuang |
| author_facet | Jin Tong-Shou Zhao Ying Liu Li-Bin Li Tong-Shuang |
| author_sort | Jin Tong-Shou |
| collection | DOAJ |
| description | An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time. |
| format | Article |
| id | doaj-art-e0fa48bfbf814e74a3d3f9a001034d9f |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e0fa48bfbf814e74a3d3f9a001034d9f2025-02-03T07:25:45ZengWileyE-Journal of Chemistry0973-49452090-98102005-01-012422823010.1155/2005/237237One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic AcidJin Tong-Shou0Zhao Ying1Liu Li-Bin2Li Tong-Shuang3College of Chemistry and Environmental Science, Hebei University, Hebei Province, Baoding 071002, ChinaCollege of Chemistry and Environmental Science, Hebei University, Hebei Province, Baoding 071002, ChinaCollege of Chemistry and Environmental Science, Hebei University, Hebei Province, Baoding 071002, ChinaCollege of Chemistry and Environmental Science, Hebei University, Hebei Province, Baoding 071002, ChinaAn efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.http://dx.doi.org/10.1155/2005/237237 |
| spellingShingle | Jin Tong-Shou Zhao Ying Liu Li-Bin Li Tong-Shuang One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid E-Journal of Chemistry |
| title | One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid |
| title_full | One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid |
| title_fullStr | One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid |
| title_full_unstemmed | One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid |
| title_short | One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid |
| title_sort | one pot synthesis of 3 4 dihydropyrimidin 2 1h ones catalyzed by chlorosulfonic acid |
| url | http://dx.doi.org/10.1155/2005/237237 |
| work_keys_str_mv | AT jintongshou onepotsynthesisof34dihydropyrimidin21honescatalyzedbychlorosulfonicacid AT zhaoying onepotsynthesisof34dihydropyrimidin21honescatalyzedbychlorosulfonicacid AT liulibin onepotsynthesisof34dihydropyrimidin21honescatalyzedbychlorosulfonicacid AT litongshuang onepotsynthesisof34dihydropyrimidin21honescatalyzedbychlorosulfonicacid |