One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction t...

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Bibliographic Details
Main Authors: Jin Tong-Shou, Zhao Ying, Liu Li-Bin, Li Tong-Shuang
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2005/237237
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