A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement

A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement

Ischemic stroke (IS) is a globally life-threatening disease. Presently, few therapeutic medicines are available for treating IS, and rt-PA is the only drug approved by the US Food and Drug Administration (FDA) in the US. In fact, many agents showing excellent neuroprotection but no blood flow-improv...

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Bibliographic Details
Main Authors: Jianbing Wu, Duorui Ji, Weijie Jiao, Jian Jia, Jiayi Zhu, Taijun Hang, Xijing Chen, Yang Ding, Yuwen Xu, Xinglong Chang, Liang Li, Qiu Liu, Yumei Cao, Yan Zhong, Xia Sun, Qingming Guo, Tuanjie Wang, Zhenzhong Wang, Ya Ling, Wei Xiao, Zhangjian Huang, Yihua Zhang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ischemic stroke
Nitric oxide
AAPB
Neuroprotection
Blood flow improvement
Dual effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000048
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