Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease

Summary: Podocytes are specialized kidney cells that form the slit diaphragm (SD), an intercellular filtration barrier against plasma protein loss. The SD is subject to significant mechanical strain which can be amplified in disease, leading to podocyte detachment. One key SD protein that might inte...

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Bibliographic Details
Main Authors: Casey R. Williamson, Claire E. Martin, J. Dinesh Kumar, Peihua Lu, Laura A. New, Alice Y. Wang, Nils M. Kronenberg, Malte C. Gather, Paul A. Reynolds, Nina Jones
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Specialized functions of cells
Biomechanics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009344
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