Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold

Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold

The glyoxalase system, particularly glyoxalase-I (GLO-I), has been approved as a potential target for cancer treatment. In this study, a set of structurally diverse polyphenolic natural compounds were investigated as potential GLO-I inhibitors. Ellagic acid was found, computationally and experimenta...

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Bibliographic Details
Main Authors: Al-Shar’i Nizar A., Al-Balas Qosay A., Hassan Mohammad A., El-Elimat Tamam M., Aljabal Ghazi A., Almaaytah Ammar M.
Format: Article
Language:English
Published: Sciendo 2021-03-01
Series:Acta Pharmaceutica
Subjects:
ellagic acid
glyoxalase-i
zinc-binding
anticancer
molecular docking
mm-gbmv
Online Access:https://doi.org/10.2478/acph-2021-0005
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https://doi.org/10.2478/acph-2021-0005

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