Techniques for Detection of Clinical Used Heparins
Heparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/5543460 |
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| _version_ | 1832566030029815808 |
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| author | Binjie Li Huimin Zhao Mingjia Yu |
| author_facet | Binjie Li Huimin Zhao Mingjia Yu |
| author_sort | Binjie Li |
| collection | DOAJ |
| description | Heparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins develop additional attention to analyze the purity of heparins. This review starts with the description of the classification, anticoagulant mechanism, clinical application of heparins and focuses on the existing methods of heparin analysis and detection including traditional detection methods, as well as new methods using fluorescence or gold nanomaterials as probes. The in-depth understanding of these techniques for the analysis of heparins will lay a foundation for the further development of novel methods for the detection of heparins. |
| format | Article |
| id | doaj-art-e090f56fd493430eb5cd20ea2fcf11d4 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-e090f56fd493430eb5cd20ea2fcf11d42025-02-03T01:05:19ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792021-01-01202110.1155/2021/55434605543460Techniques for Detection of Clinical Used HeparinsBinjie Li0Huimin Zhao1Mingjia Yu2Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, ChinaCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, ChinaBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, ChinaHeparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins develop additional attention to analyze the purity of heparins. This review starts with the description of the classification, anticoagulant mechanism, clinical application of heparins and focuses on the existing methods of heparin analysis and detection including traditional detection methods, as well as new methods using fluorescence or gold nanomaterials as probes. The in-depth understanding of these techniques for the analysis of heparins will lay a foundation for the further development of novel methods for the detection of heparins.http://dx.doi.org/10.1155/2021/5543460 |
| spellingShingle | Binjie Li Huimin Zhao Mingjia Yu Techniques for Detection of Clinical Used Heparins International Journal of Analytical Chemistry |
| title | Techniques for Detection of Clinical Used Heparins |
| title_full | Techniques for Detection of Clinical Used Heparins |
| title_fullStr | Techniques for Detection of Clinical Used Heparins |
| title_full_unstemmed | Techniques for Detection of Clinical Used Heparins |
| title_short | Techniques for Detection of Clinical Used Heparins |
| title_sort | techniques for detection of clinical used heparins |
| url | http://dx.doi.org/10.1155/2021/5543460 |
| work_keys_str_mv | AT binjieli techniquesfordetectionofclinicalusedheparins AT huiminzhao techniquesfordetectionofclinicalusedheparins AT mingjiayu techniquesfordetectionofclinicalusedheparins |