Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming

Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming

Abstract Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2IL4). Glucocorticoids (GC), widely used anti-inflammatory therapeutics, reportedly impart a similar phenotype (M2GC), but how such dispa...

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Main Authors: Dinesh K. Deochand, Marija Dacic, Michael J. Bale, Andrew W. Daman, Vidyanath Chaudhary, Steven Z. Josefowicz, David Oliver, Yurii Chinenov, Inez Rogatsky
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52942-x
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https://doi.org/10.1038/s41467-024-52942-x

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