A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis

A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis

Abstract Epigenetic changes are present in all human cancers and are responsible for switching on or off genes, thus controlling tumor cell transcriptome. These changes occur through DNA methylation, histone modifiers and readers, chromatin remodelers, and microRNAs. The histone H3 methyl-transferas...

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Main Authors: Marta C. Nocito, Constanze Hantel, Antonio M. Lerario, Fabrizio Mastrorocco, Luca De Martino, Clara Musicco, Ida D. Perrotta, Mariafrancesca Scalise, Cesare Indiveri, Sergio Giannattasio, Pierre Val, Marilena Lanzino, Vincenzo Pezzi, Ivan Casaburi, Rosa Sirianni
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07607-y
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https://doi.org/10.1038/s41419-025-07607-y

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