Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children
Objective. Systemic lupus erythematosus (SLE) is a relatively common rheumatic disease in children. The characteristics of blood lipid metabolism in children with LN are little reported. This study aimed to explore the relationship between blood lipid profiles and the risk of lupus nephritis (LN) in...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/6130774 |
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| author | Jiajia Liu Wenqi Song Dawei Cui |
| author_facet | Jiajia Liu Wenqi Song Dawei Cui |
| author_sort | Jiajia Liu |
| collection | DOAJ |
| description | Objective. Systemic lupus erythematosus (SLE) is a relatively common rheumatic disease in children. The characteristics of blood lipid metabolism in children with LN are little reported. This study aimed to explore the relationship between blood lipid profiles and the risk of lupus nephritis (LN) in children. Methods. A total of 134 children with newly diagnosed SLE were divided into LN and non-LN groups according to pathological renal biopsy results. Clinical manifestations and blood lipid profiles were analyzed and compared between the two groups, and the relationships between blood lipid profiles and risk of LN were evaluated. Results. The positivity rate of an anti-dsDNA antibody and an SLE disease activity index (SLEDAI) were significantly increased, and C3 and C4 levels were significantly reduced in the LN compared with the non-LN group. The overall incidence of dyslipidemia was 79.9%, with a significantly high incidence in the LN group compared with the non-LN group. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very LDLC (VLDL-C) were all higher in the LN group than those in the non-LN group. However, there was no significant difference in high-density lipoprotein cholesterol (HDL-C) between the two groups. The blood lipid levels were positively correlated with 24-hour urine protein quantification, urea, creatinine, uric acid, urinary IgG, urinary microalbumin, urinary transferrin, urinary α1 microglobulin, and urinary N-acetyl glucosidase, respectively. Receiver-operating characteristic curves showed that combined detection of TC, TG, LDL-C, and VLDL-C had higher discrimination capacity than that in individual measures. Additionally, increased TC was independently associated with the occurrence of LN. Conclusions. Children with LN have significant dyslipidemia. High levels of TC, TG, LDL-C, and VLDL-C are closely related to the occurrence of pLN. Clinical attention should be paid to monitoring and managing blood lipid profiles in children with LN. |
| format | Article |
| id | doaj-art-dfd60a5bdc4e44bb8a13de8de89e353b |
| institution | Kabale University |
| issn | 1742-1241 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-dfd60a5bdc4e44bb8a13de8de89e353b2025-02-03T01:22:42ZengWileyInternational Journal of Clinical Practice1742-12412022-01-01202210.1155/2022/6130774Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in ChildrenJiajia Liu0Wenqi Song1Dawei Cui2Department of Clinical Laboratory CenterDepartment of Clinical Laboratory CenterThe First Affiliated HospitalObjective. Systemic lupus erythematosus (SLE) is a relatively common rheumatic disease in children. The characteristics of blood lipid metabolism in children with LN are little reported. This study aimed to explore the relationship between blood lipid profiles and the risk of lupus nephritis (LN) in children. Methods. A total of 134 children with newly diagnosed SLE were divided into LN and non-LN groups according to pathological renal biopsy results. Clinical manifestations and blood lipid profiles were analyzed and compared between the two groups, and the relationships between blood lipid profiles and risk of LN were evaluated. Results. The positivity rate of an anti-dsDNA antibody and an SLE disease activity index (SLEDAI) were significantly increased, and C3 and C4 levels were significantly reduced in the LN compared with the non-LN group. The overall incidence of dyslipidemia was 79.9%, with a significantly high incidence in the LN group compared with the non-LN group. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very LDLC (VLDL-C) were all higher in the LN group than those in the non-LN group. However, there was no significant difference in high-density lipoprotein cholesterol (HDL-C) between the two groups. The blood lipid levels were positively correlated with 24-hour urine protein quantification, urea, creatinine, uric acid, urinary IgG, urinary microalbumin, urinary transferrin, urinary α1 microglobulin, and urinary N-acetyl glucosidase, respectively. Receiver-operating characteristic curves showed that combined detection of TC, TG, LDL-C, and VLDL-C had higher discrimination capacity than that in individual measures. Additionally, increased TC was independently associated with the occurrence of LN. Conclusions. Children with LN have significant dyslipidemia. High levels of TC, TG, LDL-C, and VLDL-C are closely related to the occurrence of pLN. Clinical attention should be paid to monitoring and managing blood lipid profiles in children with LN.http://dx.doi.org/10.1155/2022/6130774 |
| spellingShingle | Jiajia Liu Wenqi Song Dawei Cui Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children International Journal of Clinical Practice |
| title | Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children |
| title_full | Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children |
| title_fullStr | Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children |
| title_full_unstemmed | Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children |
| title_short | Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children |
| title_sort | relationship between blood lipid profiles and risk of lupus nephritis in children |
| url | http://dx.doi.org/10.1155/2022/6130774 |
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