Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pipeline that combines high-throughput screening in...

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Main Authors: Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0193889/1/pone.0193889.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210221%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210221T181024Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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