Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs

Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs

Background. The use of the bone-seeking properties of bisphosphonates (BPs) to target the delivery of therapeutic drugs is a promising approach for the treatment of bone metastases. Currently, the most advanced example of this approach is a gemcitabine-ibandronate conjugate (GEM-IB), where the bone-...

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Bibliographic Details
Main Authors: Jost Klawitter, Mckay Easton, Alexander Karpeisky, Kristen B. Farrell, Douglas H. Thamm, Touraj Shokati, Uwe Christians, Shawn Patrick Zinnen
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
bisphosphonates
bone cancer
pharmacokinetics
gemcitabine ibandronate
high-performance liquid chromatography
mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/30/2/354
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